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EU Releases Pinoxaden Risk Assessment: Deep Dive into Groundwater Impact and Metabolite Toxicity
On September 8, 2025, the European Food Safety Authority (EFSA) officially published its peer review report on the pesticide risk assessment of the active substance pinoxaden, offering a detailed risk profile for this widely used herbicide in European agricultural fields. Pinoxaden, commonly known by its trade name "Axial," effectively controls graminaceous weeds in winter and spring cereal crops by inhibiting acetyl-CoA carboxylase (ACCase). When the substance was approved in the EU in 2016, a crucial precondition was attached: given its subsequent formal classification as reproductive toxicant category 2 (H361d, suspected of damaging the unborn child), the applicant, Syngenta, was required to submit relevant risk assessment data for its specific metabolites M11, M52, M54, M55, and M56. With this toxicity classification officially adopted at the EU level, the confirmatory data assessment procedure, coordinated by Austria as the rapporteur Member State and led by EFSA, was initiated to fill the previously identified scientific gaps.
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